Dementia and role of nutrition
6 important questions on Dementia and role of nutrition
What are 4 subtypes of cognitive loss in dementia?
-amnesia (memory)
-apraxia (skilled movements)
-aphasia (language)
-agnosia (recognizing)
What are the risk factors (non)-modifiable for dementia?
-age (midlife 45-65 y 30%)
-genes (APOE e4 carriers!)
-biologic sex
Modifiable (45%)
-lifestyle ( ~nutritition) (13%)
-cardiovascular
-envionment (pollution)
-brain trauma, hearing loss, education
What are the factors that contribute to compromised nutritional status in Alzheimer's ?
✓ Feeding behaviour & nutrient absorption alterations (Blood-brain barrier (BBB))
✓ Cerebral bioenergetic alterations (e.g. ApoE, BBB disruptions (leaky))
✓ Increased utilization of nutrients (high energy demand)
✓ ↑↑ plasma [homocysteine] ≈ ↓ decreased [vitB12] ≈ ↓ mobilization of DHA from
liver into plasma
✓ ↓ uptake of choline ≈ ↑↑ degradation of neuronal membrane phosphatidylcholine
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Explain the MIND/MedDiet/DASH and the effect of the risk on AD
DASH: dietary approaches to stop hypertension
MIND diet: Mediterranean-DASH Intervention for Neurodegenerative Delay (score van 0.15)
53% reduction of AD risk in highest tertile
➢ 35% reduction of AD risk in middle tertiles
What does MIND stand for in the mind diet and what are a few food groups out of this?
What would be the best treatment for people with early dementia?
Treatment-wise, one could suggest to opt for nutraceuticals, MCT oils (preferable C8:C10) or
probiotics as an add-on to routine pharmacotherapy IN those afflicted with early
dementia (Alzheimer’s disease)
The question on the page originate from the summary of the following study material:
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