Role of nutrition in epigenetics - Give examples of research findings supporting a link between nutrition, epigenetics, and brain/mental health at different stages of the life course (perinatal, childhood, aging)

7 important questions on Role of nutrition in epigenetics - Give examples of research findings supporting a link between nutrition, epigenetics, and brain/mental health at different stages of the life course (perinatal, childhood, aging)

How can nutrients influence DNAm?

Nutrients can influence DNAm via direct or indirect modulation of
-the availability of methyl donor molecules
-activity of enzymes involved in adding / removing methyl groups from the DNA (DNMTs)
-transcription factors, transcriptional activity becomes epigenetically stabilized

What does study about maternal folate and child epigenetics show?

This study about maternal folate shows that prenatal nutrition shapes the neonatal genome

How are folate, b-vitamins and epigenetics linked?

From Folate and B vitamins, methyl groups are formed via biochemical reacitons called one-carbon metabolism. B12 and folate involved in the avalaibility of a methyl group
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What is the conclusion from the study about DNA methylation and lactose intolerance?

In this study methylation at 3 CpG sites were measured, three different phenotypes
there is clear that genetic variance plays a very big part in lactose intolerance/tolerance

What are two ways to measure inflammation?

Two ways to measure inflammation are
-inflammation signaling molecules   (CRP)
-epigenetics immune cells

What are 4 reasons that blood DNAm is a good future potential as a immune biomarker?

Blood DNAm is a potential immune biomarker because
-reflects current and previous immune activity in a relative stable manner
-epigenetic regulation immune system development
-training/priming of future immune responses
-accessibility (target tissue systemic inflammation)

Which mental health disorder is associated with accelarated aging?

Schizophrenia is associated with accelerated aging

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