Ketones versus glucose

8 important questions on Ketones versus glucose

What happens to the body during fasting?

During fasting to body starts drawing from its internal fuel reserves, the first of being glycogen. Once depleted, the body turns to fat reserves. Fatty acids are released from adipose tissue and transported to the liver, where they are converted into ketone bodies: → acetoacetate, beta-hydroxybutyrate, and acetone.

How well does the brain function without glucose?

The brain can technically function without glucose, but certain processes do require glucose. Ketones cannot fully replace all the demands (can replace 60%). The body can also derive glucose from gluconeogenesis

What is threshold line of being in ketosis?

You are in ketosis when you have 0,5 mmol/L ketonenen per liter bloed
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What are the 5 functions of ketones?

5 functions of ketones
-energy
-signalling molecules
-influence gene expression
-reduce chronic inflammation
-neuroprotection

What is the definition of ketogenic interventions and name three of them?

Ketogenic interventions are interventions that lead to ketones appearing in your blood
-fasting
- supplements(coconut oil, MCT oil, exogeneous ketones)
-ketogenic diet (low carb, moderate protein, high fat)

What is the advantage of each ketogenic interventions?

Diet: provides the effects of ketones as molecules but also supports processes
such as restoring hormonal balance.
• Fasting: Gives the gut a rest, which diet and supplements don’t do. Much
research focuses on autophagy during fasting (the clearing out of cellular
“waste”), which has not been studied extensively for the diet or supplements.
• Exogenous ketones: Here you only get the molecular effects, but not the other
benefits. Which in some situations might be enough

When can a ketogenic diet be dangerous?

A ketogenic diet can be dangerous when there is risk of ketoacidosis (> 8 - 10 mmol/L). At very high concentrations blood comes too acidic - this is life threatening. Risk mainly in unctrolled diabetes. In healthy individuals there is a negative feedback loop

What are 5 contra indications of a keto genic interventions?

5 contra indication of ketogenic interventions
-uncontrolled diabetes
-metabolic disorders
-disturbed lipid profile
-cardiovascular risk
-certain medications

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