Parkinson's disease: basics and role of nutrition - Treatment

4 important questions on Parkinson's disease: basics and role of nutrition - Treatment

What are 6 parkinson disease drugs?

-L-DOPA (most common) (fixed combination with decarboxylase-inhibitor)
-DDC inhibitors
-COMT inhibitors (peripheral)
-COMT inhibitors (central)
-MAO-B inhibitors
-Dopamine Agonists

What changes throughout the disease proces of Parkinson?


-nigral buffering capacity decreases
-duration of effect of single levodopa dose
ealry> 6 hours to days
late: 2 hours
-pulsatile stimulation of striatal dopamin receptors leads to
  post-synaptic changes

What happens to the therapeutic window in PD?

The therapeutic window in PD gets smallers. The upper limit is the dyskinesia threshold: too much erratic movements. The lower limit is the bradykinesia; too much slow movement. Overtime the buffering capacity decreases, so a normal dose of levodopa can cause an overshoot
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What are  3 forms of advanced treatment for PD?

-LCIG pump: levodopa-carbidopa intestinal gel pump
-subcutaneous infusion
-deep brain stimulation

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